Phenotypic heterogeneity of sitosterolemia

Phenotypic heterogeneity of MELAS☆☆☆

With interest we read the article by Dvorakova et al. about 50 Czech patients carrying the m.3243ANG mutation [1]. It raises questions and concerns. Since MELAS is a progressive disease, we should be informed about the long-term follow-up findings in the 50 mutation carriers. How many of the 17 patients without clinical manifestations at inclusion developed MELAS during follow-up? How many of t...

Phenotypic Heterogeneity of the Endothelium

Endothelial cells, which form the inner cellular lining of blood vessels and lymphatics, display remarkable heterogeneity in structure and function. This is the second of a 2-part review on the phenotypic heterogeneity of blood vessel endothelial cells. The first part discusses the scope, the underlying mechanisms, and the diagnostic and therapeutic implications of phenotypic heterogeneity. Her...

Phenotypic Heterogeneity of Breast Tumors

Phenotypic Heterogeneity in Bacterial Populations

Genetically uniform bacterial cells exhibit heterogeneity such as intrapopulation differences in metabolism as well as variation in growth rate. Additionally, phenotypic heterogeneity in more complex developmental processes where a portion of a population performs specialized functions has been described. Heterogeneity within populations of bacterial cells ensures that a small fraction of the p...

microRNAs suppress cellular phenotypic heterogeneity

microRNAs are small noncoding RNAs that reduce protein output from complementary target mRNA transcripts. They are a conserved family of gene regulators in multicellular organisms, targeting much of the transcriptome. This pervasiveness is at odds with their generally modest repressive capacity, and suggests that microRNAs might not be cellular decision makers; rather they might ensure the stab...